龚燚 教授、硕士生导师

研究方向：水产动物病害防控与免疫调控

主要荣誉及专业团队任职：广东省“杨帆计划”入选者，水生水产研究所PI

邮箱：gongyi@ncu.edu.cn

教育经历：

1: 2012/09—2017/07 浙江大学，新葡亰8883ent，博士研究生/博士

2: 2008/09—2012/07 电子科技大学，生命科学与技术学院，本科/学士

工作经历：

1: 2022/09—至今 新葡亰8883ent，新葡亰8883ent，教授

2: 2017/07—2022/09 汕头大学，理学院，讲师

执教课程：

本科生课程：《微生物学》

研究生课程：无

主持课题项目：

1. 国家自然科学基金面上项目，外泌体miRNA调控拟穴青蟹血淋巴菌群稳态的分子机制研究(32173006)，2022.01-2025.12，在研。

2. 国家自然科学基金青年科学基金项目，外泌体miRNA在拟穴青蟹抗病毒免疫调控中的功能研究(31802341)，2019.01-2021.12，结题。

3. 广东省自然科学基金，p53蛋白泛素化修饰在拟穴青蟹抵御WSSV侵染过程中的功能研究(2018A030307044)，2018.05-2021.04，结题。

4. 广东省普通高校青年创新人才项目，Bcl-2基因介导的抗凋亡途径在拟穴青蟹抵抗WSSV侵染中作用的研究(2017KQNCX072)，2018.01-2019.12，结题。

代表性论文：

1. Gong Y, Wei XY, Sun WW, Ren X, Chen J, Aweya JJ, Ma HY, Chan KG, Zhang YL*, Li SK*. Exosomal miR-224 contributes to hemolymph microbiota homeostasis during bacterial infection in crustacean. PLoS Pathogens, 2021, 17(8): e1009837.

2. Gong Y, Kong TT, Ren X, Chen J, Lin SM, Zhang YL, Li SK*. Exosome-mediated apoptosis pathway during WSSV infection in crustacean mud crab. PLoS Pathogens, 2020, 16(5): e1008366.

3. Gong Y, Kong TT, Aweya JJ, Ma HY, Zhang YL, Li SK*. p53 ubiquitination co-mediated by HUWE1 and TRAF6 contributes to White spot syndrome virus infection in crustacean. Journal of Virology, 2022, 96(6): e02029-21.

4. Gong Y, Ju CY, Zhang XB*. Shrimp miR-1000 functions in antiviral immunity by simultaneously triggering the degradation of two viral mRNAs. Frontiers in Immunology, 2018, 9: 02999.

5. Gong Y, Kong TT, Ren X, Lin SM, Li SK*. miR-9875 functions in antiviral immunity by targeting PDCD6 in mud crab (Scylla paramamosain). Virulence, 2020, 11(1): 849-862.

6. Hu H, Zhao XS, Li SK, Gong Y*. SpICAD contributes to WSSV infection by suppressing apoptosis in mud crab (Scylla paramamosain). Aquaculture, 2021, 536: 736449.

7. Hu H, Zhao XS, Cui YL, Li SK, Gong Y*. SpTIA-1 suppresses WSSV infection by promoting apoptosis in mud crab (Scylla paramamosain). Molecular Immunology, 2021, 140: 158-166.

8. Kong TT, Ren X, Lin SM, Li SK, Gong Y*. Elucidation of metabolic responses in mud crab Scylla paramamosain challenged to WSSV infection by integration of metabolomics and transcriptomics. Developmental & Comparative Immunology, 2020, 113: 103799.

9. Gong Y, Yang G, Wang QZ, Wang YM, Zhang XB*. NME2 is a master suppressor of apoptosis in gastric cancer cells via transcriptional regulation of miR-100 and other survival factors. Molecular Cancer Research, 2020, 18: 287-299.

10. Yang G#, Gong Y#, Wang QZ, Wang LP, Zhang XB*. miR-100 antagonism triggers apoptosis by inhibiting ubiquitination-mediated p53 degradation. Oncogene, 2016, 36(8): 1023-1038. (共同第一作者)

11. Gong Y, Zhang XB*. RNAi-based antiviral immunity of shrimp. Developmental & Comparative Immunology, 2021, 115: 103907.

12. Gong Y, Chen J, Cui YL, Li SK*. miR-2 contributes to WSSV infection by targeting Caspase 2 in mud crab (Scylla paramamosain). Developmental & Comparative Immunology, 2021, 125: 104217.

13. Lin SM, Kong TT, Ren X, Li SK, Gong Y*. Elucidation of gut microbiota in mud crab Scylla paramamosain challenged to WSSV and Aeromonas hydrophila. Marine Biotechnology, 2020, 22: 661-672

14. Kong TT, Lin SM, Ren X, Li SK, Gong Y*. Transcriptome and metabolome integration analysis of mud crab Scylla paramamosain challenged to Vibrio parahaemolyticus infection. Fish & shellfish immunology, 2020, 103: 430-437.

15. Gong Y, He TL, Yang L, Yang G, Chen YL, Zhang XB*. The role of miR-100 in regulating apoptosis of breast cancer cells. Scientific Reports, 2015, 5, 11650.

16. Gong Y, Ju CY, Zhang XB*. The miR-1000-p53 pathway regulates apoptosis and virus infection in shrimp. Fish & shellfish immunology, 2015, 46(2): 516-522.

17. Liu T, Lin SM, Du YY, Gong Y*, Li SK*. SpBAG3 assisted WSSV infection in mud crab (Scylla paramamosain) by inhibiting apoptosis. Developmental & Comparative Immunology, 2022, 129: 104349. (共同通讯作者)

18. Chen J#, Gong Y#, Zheng HP, Ma HY, Aweya JJ, Zhang YL, Chen XH, Li SK*. SpBcl2 promotes WSSV infection by suppressing apoptotic activity of hemocytes in mud crab, Scylla paramamosain. Developmental & Comparative Immunology, 2019, 100: 103421. (共同第一作者)

19. Yang G#, Gong Y#, Wang QZ, Wang YM, Zhang XB*. The role of miR-100-mediated notch pathway in apoptosis of gastric tumor cells, Cellular Signalling, 2015, 27(6): 1087-1101. (共同第一作者)